I am reaching out to raise an alarm about the world’s first human metapneumovirus (HMPV) related death reported in Bangladesh highlighting an urgent global health concern on 16 January 2025 (Anadolu Agency, 2025). This 30-year-old woman with pre- existing health comorbidities is a harbinger of systemic vulnerabilities in basic healthcare delivery systems and -- this incident will be a wake-up call for low-income countries. HMPV's ability to cause severe respiratory infections, especially in at-risk groups such as young children, older adults, and those with chronic diseases, makes this case a priority for global concern (Jamil, Sohel, & Muhammad, 2025). HMPV has spread in Bangladesh since 2017, but the recorded first fatality underscores the lack of early detection public health education, and clinical preparedness (The Daily Star, 2025). In the absence of a specific antiviral agent or vaccine, improved supportive care, including hydration, oxygen therapy, and mechanical ventilation (BSS, 2025). What happened in Bangladesh is not an anomaly but a manifestation of vulnerabilities endemic to low-income countries around the world. Diagnostic skills are limited, struggles for intensive care resources are common and healthcare workers lack the relevant training — all of which make these countries ill-equipped to effectively treat emerging infectious diseases such as COVID-19 (The Business Standard, 2025).